Engineered Fc-glycosylation switch to eliminate antibody effector function

• Main Authors: Qun Zhou (Author), Julie Jaworski (Author), Yanfeng Zhou (Author), Delphine Valente (Author), Joanne Cotton (Author), Denise Honey (Author), Ekaterina Boudanova (Author), Jochen Beninga (Author), Ercole Rao (Author), Ronnie Wei (Author), Christine Mauriac (Author), Clark Pan (Author), Anna Park (Author), Huawei Qiu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...