Engineered Fc-glycosylation switch to eliminate antibody effector function
Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...
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Taylor & Francis Group,
2020-01-01T00:00:00Z.
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