Engineered Fc-glycosylation switch to eliminate antibody effector function

• প্রধান লেখক: Qun Zhou (লেখক), Julie Jaworski (লেখক), Yanfeng Zhou (লেখক), Delphine Valente (লেখক), Joanne Cotton (লেখক), Denise Honey (লেখক), Ekaterina Boudanova (লেখক), Jochen Beninga (লেখক), Ercole Rao (লেখক), Ronnie Wei (লেখক), Christine Mauriac (লেখক), Clark Pan (লেখক), Anna Park (লেখক), Huawei Qiu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...