Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry

• Main Authors: Shivani Baisiwala (Author), Brenda Auffinger (Author), Seamus P. Caragher (Author), Jack M. Shireman (Author), Riasat Ahsan (Author), Gina Lee (Author), Tanwir Hasan (Author), Cheol Park (Author), Miranda R. Saathoff (Author), Anne C. Christensen (Author), Atique U. Ahmed (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor affecting adults, with a median survival of approximately 21 months. One key factor underlying the limited efficacy of current treatment modalities is the remarkable plasticity exhibited by GBM cells, which allows the...