<i>ERCC1</i> and <i>ERCC2</i> Polymorphisms Predict the Efficacy and Toxicity of Platinum-Based Chemotherapy in Small Cell Lung Cancer

• Autores principales: Andrés Barba (Autor), Laura López-Vilaró (Autor), Malena Ferre (Autor), Margarita Majem (Autor), Sergio Martinez-Recio (Autor), Olga Bell (Autor), María J. Arranz (Autor), Juliana Salazar (Autor), Ivana Sullivan (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2024-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Standard first-line chemotherapy in small cell lung cancer (SCLC) is based on the platinum plus etoposide combination. Despite a high objective response rate, responses are not durable and chemotherapy-induced toxicity may compromise treatment. Genetic variants in genes involved in the DNA-repair pa...