Pharmacokinetic and pharmacodynamic assessments of atogepant in healthy male adults: Results from phase 1 studies

• Main Authors: Ramesh Boinpally (Author), Marleen Depré (Author), Griet Van Lancker (Author), Marissa F Dockendorf (Author), Phung Bondiskey (Author), Jean-Francois Denef (Author), Tom Reynders (Author), Catherine Zhou Matthews (Author), K Chris Min (Author), Jialin Xu (Author), Joel M Trugman (Author), Jan de Hoon (Author)
• Format: Book
• Published: SAGE Publishing, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Hypothesis: Atogepant, an oral calcitonin gene-related peptide receptor antagonist, is approved for the preventive treatment of migraine in adults. This manuscript characterizes the safety, tolerability, pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of atogepant in hea...