Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice

• Main Authors: Sang Bum Suh (Author), Nayoung Lee (Author), Jaedeok Kim (Author), Saeha Kim (Author), Sooyeon Jang (Author), Jong Kook Park (Author), Keunwook Lee (Author), Soo Young Choi (Author), Hyung-Joo Kwon (Author), Chan Hee Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Olanzapine (OLZ), a widely used second-generation antipsychotic drug, is known to cause metabolic side effects, including diabetes and obesity. Interestingly, OLZ-induced metabolic side effects have been demonstrated to be more profound in females in human studies and animal models. Metformin (MET)...