Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death

• Main Authors: Haruna Ebisu (Author), Kana Shintani (Author), Takumi Chinen (Author), Yoko Nagumo (Author), Shuya Shioda (Author), Taisei Hatanaka (Author), Akira Sakakura (Author), Ichiro Hayakawa (Author), Hideo Kigoshi (Author), Takeo Usui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy. γ-Tubulin is a possible target as antitumor drugs with low side effects, but the antitumor effect of γ-tubulin inhi...