Process Study on the Enzyme-Catalyzed Preparation of Key Chiral Intermediates for Saxagliptin

• Main Authors: Shan-Shan Li (Author), Zong-Qing Huang (Author), Hao-Ju Hua (Author), Jian-Guang Lu (Author), Wen-Jie Zhao (Author), Jun Feng (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Saxagliptin is a therapeutic drug for diabetes. The key synthesis process of the drug involves catalyzing 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (A) into (S)-3-hydroxyadamantane glycine (B), during which enzymes phenylalanine dehydrogenase mutant from Thermoactinomyces intermedius (TiPDHm) and f...