Process Study on the Enzyme-Catalyzed Preparation of Key Chiral Intermediates for Saxagliptin

• Auteurs principaux: Shan-Shan Li (Auteur), Zong-Qing Huang (Auteur), Hao-Ju Hua (Auteur), Jian-Guang Lu (Auteur), Wen-Jie Zhao (Auteur), Jun Feng (Auteur)
• Format: Livre
• Publié: Georg Thieme Verlag KG, 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Saxagliptin is a therapeutic drug for diabetes. The key synthesis process of the drug involves catalyzing 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (A) into (S)-3-hydroxyadamantane glycine (B), during which enzymes phenylalanine dehydrogenase mutant from Thermoactinomyces intermedius (TiPDHm) and f...