Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism

• Hoofdauteurs: J.D. Gothié (Auteur), A. Sébillot (Auteur), C. Luongo (Auteur), M. Legendre (Auteur), C. Nguyen Van (Auteur), K. Le Blay (Auteur), M. Perret-Jeanneret (Auteur), S. Remaud (Auteur), B.A. Demeneix (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2017-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and glial cells. Thyroid hormones (THs) regulate adult NSC differentiation towards a neuronal phenotype, but also have major roles in mitochondrial metabolism. As NSC metabolism rel...