Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism

• Main Authors: J.D. Gothié (Author), A. Sébillot (Author), C. Luongo (Author), M. Legendre (Author), C. Nguyen Van (Author), K. Le Blay (Author), M. Perret-Jeanneret (Author), S. Remaud (Author), B.A. Demeneix (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and glial cells. Thyroid hormones (THs) regulate adult NSC differentiation towards a neuronal phenotype, but also have major roles in mitochondrial metabolism. As NSC metabolism rel...