Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

• Main Authors: Shaza Asif (Author), Ri Youn Kim (Author), Thet Fatica (Author), Jordan Sim (Author), Xiaoling Zhao (Author), Yena Oh (Author), Alix Denoncourt (Author), Angela C. Cheung (Author), Michael Downey (Author), Erin E. Mulvihill (Author), Kyoung-Han Kim (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development of the fatty liver. Here we aimed to determine...