Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

• 主要な著者: Anne Fougerat (著者), Xuefang Pan (著者), Victoria Smutova (著者), Nikolaus Heveker (著者), Christopher W. Cairo (著者), Tarik Issad (著者), Bruno Larrivée (著者), Jeffrey A. Medin (著者), Alexey V. Pshezhetsky (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2018-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NE...