Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

• Main Authors: Anne Fougerat (Author), Xuefang Pan (Author), Victoria Smutova (Author), Nikolaus Heveker (Author), Christopher W. Cairo (Author), Tarik Issad (Author), Bruno Larrivée (Author), Jeffrey A. Medin (Author), Alexey V. Pshezhetsky (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NE...