Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes.

• Главные авторы: Emir Salas-Sarduy (Автор), Lionel Urán Landaburu (Автор), Adriana K Carmona (Автор), Juan José Cazzulo (Автор), Fernán Agüero (Автор), Vanina E Alvarez (Автор), Gabriela T Niemirowicz (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Предметы: article
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Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including Trypanosoma brucei and Trypanosoma cruzi, the causative agents of sleeping sickness and Chagas disease, respectively. These enzymes are absent...