Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes.

• Main Authors: Emir Salas-Sarduy (Author), Lionel Urán Landaburu (Author), Adriana K Carmona (Author), Juan José Cazzulo (Author), Fernán Agüero (Author), Vanina E Alvarez (Author), Gabriela T Niemirowicz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including Trypanosoma brucei and Trypanosoma cruzi, the causative agents of sleeping sickness and Chagas disease, respectively. These enzymes are absent...