Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes.

• Hoofdauteurs: Emir Salas-Sarduy (Auteur), Lionel Urán Landaburu (Auteur), Adriana K Carmona (Auteur), Juan José Cazzulo (Auteur), Fernán Agüero (Auteur), Vanina E Alvarez (Auteur), Gabriela T Niemirowicz (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including Trypanosoma brucei and Trypanosoma cruzi, the causative agents of sleeping sickness and Chagas disease, respectively. These enzymes are absent...