New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

• Main Authors: Luc H. Boudreau (Author), Grégoire Lassalle-Claux (Author), Marc Cormier (Author), Sébastien Blanchard (Author), Marco S. Doucet (Author), Marc E. Surette (Author), Mohamed Touaibia (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis of leukotrienes and is thus a validated thera...