New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

• Egile Nagusiak: Luc H. Boudreau (Egilea), Grégoire Lassalle-Claux (Egilea), Marc Cormier (Egilea), Sébastien Blanchard (Egilea), Marco S. Doucet (Egilea), Marc E. Surette (Egilea), Mohamed Touaibia (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2017-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Leukotrienes are inflammatory mediators that actively participate in the inflammatory response and host defense against pathogens. However, leukotrienes also participate in chronic inflammatory diseases. 5-lipoxygenase is a key enzyme in the biosynthesis of leukotrienes and is thus a validated thera...