A lipopeptide facilitate induction of Mycobacterium leprae killing in host cells.

• Main Authors: Yumi Maeda (Author), Toshiki Tamura (Author), Yasuo Fukutomi (Author), Tetsu Mukai (Author), Masanori Kai (Author), Masahiko Makino (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Little is known of the direct microbicidal activity of T cells in leprosy, so a lipopeptide consisting of the N-terminal 13 amino acids lipopeptide (LipoK) of a 33-kD lipoprotein of Mycobacterium leprae, was synthesized. LipoK activated M. leprae infected human dendritic cells (DCs) to induce the pr...