A lipopeptide facilitate induction of Mycobacterium leprae killing in host cells.

• Үндсэн зохиолчид: Yumi Maeda (Зохиогч), Toshiki Tamura (Зохиогч), Yasuo Fukutomi (Зохиогч), Tetsu Mukai (Зохиогч), Masanori Kai (Зохиогч), Masahiko Makino (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Little is known of the direct microbicidal activity of T cells in leprosy, so a lipopeptide consisting of the N-terminal 13 amino acids lipopeptide (LipoK) of a 33-kD lipoprotein of Mycobacterium leprae, was synthesized. LipoK activated M. leprae infected human dendritic cells (DCs) to induce the pr...