A lipopeptide facilitate induction of Mycobacterium leprae killing in host cells.

• Główni autorzy: Yumi Maeda (Autor), Toshiki Tamura (Autor), Yasuo Fukutomi (Autor), Tetsu Mukai (Autor), Masanori Kai (Autor), Masahiko Makino (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Little is known of the direct microbicidal activity of T cells in leprosy, so a lipopeptide consisting of the N-terminal 13 amino acids lipopeptide (LipoK) of a 33-kD lipoprotein of Mycobacterium leprae, was synthesized. LipoK activated M. leprae infected human dendritic cells (DCs) to induce the pr...