Constitutively Active Mutant N111G of Angiotensin II Type 1 (AT1) Receptor Induces Homologous Internalization Through Mediation of AT1-Receptor Antagonist

• Main Authors: Mohiuddin Ahmed Bhuiyan (Author), Murad Hossain (Author), Shin-ichiro Miura (Author), Takashi Nakamura (Author), Masanobu Ozaki (Author), Takafumi Nagatomo (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study investigated the internalization behavior of the constitutively active mutant (CAM) N111G of angiotensin II type 1 (AT1) receptor and correlated the result with the mechanism of the constitutive activity of the mutant. The inverse agonist activity of valsartan, losartan, candesarta...