Extracellular CIRP induces CD4CD8αα intraepithelial lymphocyte cytotoxicity in sepsis

• Main Authors: Yuichi Akama (Author), Atsushi Murao (Author), Monowar Aziz (Author), Ping Wang (Author)
• Format: Knjiga
• Izdano: BMC, 2024-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background In sepsis, intestinal barrier dysfunction is often caused by the uncontrolled death of intestinal epithelial cells (IECs). CD4CD8αα intraepithelial lymphocytes (IELs), a subtype of CD4+ T cells residing within the intestinal epithelium, exert cytotoxicity by producing granzyme B...