CoMFA and docking study of 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as novel PfDHFR enzyme inhibitors for antimalarial activity

A three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on 1,3,5-triazine derivatives which were based on Ala16Val + Ser108Thr mutant DHFR inhibitors of Plasmodium falciparum clone (FCR-3). Comparative Molecular Field Analysis (CoMFA) was carried out for design...

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Main Authors: Pritam N. Dube (Author), Santosh Mokale (Author), Prasanna Datar (Author)
Format: Book
Published: Faculty of Pharmacy, Cairo University, 2014-06-01T00:00:00Z.
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3rd Floor Main Library

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