CoMFA and docking study of 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as novel PfDHFR enzyme inhibitors for antimalarial activity

• 主要な著者: Pritam N. Dube (著者), Santosh Mokale (著者), Prasanna Datar (著者)
• フォーマット: 図書
• 出版事項: Faculty of Pharmacy, Cairo University, 2014-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on 1,3,5-triazine derivatives which were based on Ala16Val + Ser108Thr mutant DHFR inhibitors of Plasmodium falciparum clone (FCR-3). Comparative Molecular Field Analysis (CoMFA) was carried out for design...