Antifungal Activity of Amphotericin B Conjugated to Nanosized Magnetite in the Treatment of Paracoccidioidomycosis.

• Main Authors: Camila Arruda Saldanha (Author), Mônica Pereira Garcia (Author), Diego Cesar Iocca (Author), Luciana Guilherme Rebelo (Author), Ana Camila Oliveira Souza (Author), Anamélia Lorenzetti Bocca (Author), Maria de Fátima Menezes Almeida Santos (Author), Paulo Cesar Morais (Author), Ricardo Bentes Azevedo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study reports on in vitro and in vivo tests that sought to assess the antifungal activity of a newly developed magnetic carrier system comprising amphotericin B loaded onto the surface of pre-coated (with a double-layer of lauric acid) magnetite nanoparticles. The in vitro tests compared two dr...