Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats

• Egile Nagusiak: Felipe Patricio (Egilea), Eliud Morales Dávila (Egilea), Aleidy Patricio-Martínez (Egilea), Nayeli Arana Del Carmen (Egilea), Isabel Martínez (Egilea), José Aguilera (Egilea), Jose Manuel Perez-Aguilar (Egilea), Ilhuicamina Daniel Limón (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cannabidiol (CBD) presents antiparkinsonian properties and neuromodulatory effects, possibly due to the pleiotropic activity caused at multiple molecular targets. Recently, the GPR55 receptor has emerged as a molecular target of CBD. Interestingly, GPR55 mRNA is expressed in the external globus pall...