Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis

• Autores principales: Kai-Wen Cheng (Autor), Chih-Hua Tseng (Autor), I.-Ju Chen (Autor), Bo-Cheng Huang (Autor), Hui-Ju Liu (Autor), Kai-Wen Ho (Autor), Wen-Wei Lin (Autor), Chih-Hung Chuang (Autor), Ming-Yii Huang (Autor), Yu-Lin Leu (Autor), Steve R. Roffler (Autor), Jaw-Yuan Wang (Autor), Yeh-Long Chen (Autor), Tian-Lu Cheng (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The bidirectional interaction between carcinogens and gut microbiota that contributes to colorectal cancer is complicated. Reactivation of carcinogen metabolites by microbial β-glucuronidase (βG) in the gut potentially plays an important role in colorectal carcinogenesis. We assessed the chemoprotec...