Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis

• Main Authors: Kai-Wen Cheng (Author), Chih-Hua Tseng (Author), I.-Ju Chen (Author), Bo-Cheng Huang (Author), Hui-Ju Liu (Author), Kai-Wen Ho (Author), Wen-Wei Lin (Author), Chih-Hung Chuang (Author), Ming-Yii Huang (Author), Yu-Lin Leu (Author), Steve R. Roffler (Author), Jaw-Yuan Wang (Author), Yeh-Long Chen (Author), Tian-Lu Cheng (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bidirectional interaction between carcinogens and gut microbiota that contributes to colorectal cancer is complicated. Reactivation of carcinogen metabolites by microbial β-glucuronidase (βG) in the gut potentially plays an important role in colorectal carcinogenesis. We assessed the chemoprotec...