<i>Para</i>-N-Methylpyridinium Pyrenes: Impact of Positive Charge on ds-DNA/RNA and Protein Recognition, Photo-Induced Bioactivity, and Intracellular Localisation

• Principais autores: Marta Košćak (Autor), Isabela Pehar (Autor), Ksenija Božinović (Autor), Goutam Kumar Kole (Autor), Sandra Sobočanec (Autor), Iva I. Podgorski (Autor), Marija Pinterić (Autor), Klaus Müller-Buschbaum (Autor), Dragomira Majhen (Autor), Ivo Piantanida (Autor), Todd B. Marder (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The 2- and 2,7- substituted <i>para</i>-N-methylpyridinium pyrene cations show high-affinity intercalation into ds-DNAs, whereas their non-methylated analogues interacted with ds-DNA/RNA only in the protonated form (at pH 5), but not at physiological conditions (pH 7). The fluorescence f...