<i>Para</i>-N-Methylpyridinium Pyrenes: Impact of Positive Charge on ds-DNA/RNA and Protein Recognition, Photo-Induced Bioactivity, and Intracellular Localisation

• Main Authors: Marta Košćak (Author), Isabela Pehar (Author), Ksenija Božinović (Author), Goutam Kumar Kole (Author), Sandra Sobočanec (Author), Iva I. Podgorski (Author), Marija Pinterić (Author), Klaus Müller-Buschbaum (Author), Dragomira Majhen (Author), Ivo Piantanida (Author), Todd B. Marder (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 2- and 2,7- substituted <i>para</i>-N-methylpyridinium pyrene cations show high-affinity intercalation into ds-DNAs, whereas their non-methylated analogues interacted with ds-DNA/RNA only in the protonated form (at pH 5), but not at physiological conditions (pH 7). The fluorescence f...