<i>Para</i>-N-Methylpyridinium Pyrenes: Impact of Positive Charge on ds-DNA/RNA and Protein Recognition, Photo-Induced Bioactivity, and Intracellular Localisation

• Главные авторы: Marta Košćak (Автор), Isabela Pehar (Автор), Ksenija Božinović (Автор), Goutam Kumar Kole (Автор), Sandra Sobočanec (Автор), Iva I. Podgorski (Автор), Marija Pinterić (Автор), Klaus Müller-Buschbaum (Автор), Dragomira Majhen (Автор), Ivo Piantanida (Автор), Todd B. Marder (Автор)
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• Опубликовано: MDPI AG, 2022-11-01T00:00:00Z.
• Предметы: article
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The 2- and 2,7- substituted <i>para</i>-N-methylpyridinium pyrene cations show high-affinity intercalation into ds-DNAs, whereas their non-methylated analogues interacted with ds-DNA/RNA only in the protonated form (at pH 5), but not at physiological conditions (pH 7). The fluorescence f...