Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats

• Autori principali: Ami Miller (Autore), Stephen Carr (Autore), Terry Rabbitts (Autore), Hanif Ali (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The success of therapeutic antibodies is largely attributed for their exquisite specificity, homogeneity, and functionality. There is, however, a need to engineer antibodies to extend and enhance their potency. One parameter is functional affinity augmentation, since antibodies matured in vivo have...