Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats

• 主要な著者: Ami Miller (著者), Stephen Carr (著者), Terry Rabbitts (著者), Hanif Ali (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The success of therapeutic antibodies is largely attributed for their exquisite specificity, homogeneity, and functionality. There is, however, a need to engineer antibodies to extend and enhance their potency. One parameter is functional affinity augmentation, since antibodies matured in vivo have...