Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells

• Main Authors: Yang Yang (Author), Qi-Shan Zeng (Author), Min Zou (Author), Jian Zeng (Author), Jiao Nie (Author), DongFeng Chen (Author), Hua-Tian Gan (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Intestinal fibrosis is a consequence of continuous inflammatory responses that negatively affect the quality of life of patients. By screening altered proteomic profiles of mouse fibrotic colon tissues, we identified that GREM1 was dramatically upregulated in comparison to that in normal tissues. Fu...