Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF

• Egile Nagusiak: Mina Tanabe (Egilea), Kanako Hosono (Egilea), Atsushi Yamashita (Egilea), Yoshiya Ito (Egilea), Masataka Majima (Egilea), Shuh Narumiya (Egilea), Chika Kusano (Egilea), Hideki Amano (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Acetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure. Macrophages are key players in liver restoration following APAP-induced liver injury. Thromboxane A2 (TXA2) and its receptor, thromboxane prostanoid (TP) receptor, have been shown to be inv...