Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF

• Main Authors: Mina Tanabe (Author), Kanako Hosono (Author), Atsushi Yamashita (Author), Yoshiya Ito (Author), Masataka Majima (Author), Shuh Narumiya (Author), Chika Kusano (Author), Hideki Amano (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Acetaminophen (APAP)-induced liver injury is the most common cause of acute liver failure. Macrophages are key players in liver restoration following APAP-induced liver injury. Thromboxane A2 (TXA2) and its receptor, thromboxane prostanoid (TP) receptor, have been shown to be inv...