PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva

• Asıl Yazarlar: Zheng Guan (Yazar), Gabriel Jacobs (Yazar), Hans vanPelt (Yazar), Joop M.A. Van Gerven (Yazar), Jacobus Burggraaf (Yazar), Wei Zhao (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2020-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract This research was planned to build a Pharmacokinetic/Pharmacodynamic (PK/PD) model of 5‐hydroxytryptophan (5‐HTP) challenge study including a circadian rhythm component of cortisol and to predict serum cortisol based on saliva cortisol. Data from three 5‐HTP challenge studies in healthy vol...