PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva

• Autors principals: Zheng Guan (Autor), Gabriel Jacobs (Autor), Hans vanPelt (Autor), Joop M.A. Van Gerven (Autor), Jacobus Burggraaf (Autor), Wei Zhao (Autor)
• Format: Llibre
• Publicat: Wiley, 2020-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract This research was planned to build a Pharmacokinetic/Pharmacodynamic (PK/PD) model of 5‐hydroxytryptophan (5‐HTP) challenge study including a circadian rhythm component of cortisol and to predict serum cortisol based on saliva cortisol. Data from three 5‐HTP challenge studies in healthy vol...