Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer

• Main Authors: Alsmawal A. Elimam (Author), Mohamed Elmogtba Mouaweia Mohamed Aabdein (Author), Mohamed El-Fatih Moly Eldeen (Author), Hisham N. Altayb (Author), Mohamed Adel Taha (Author), Mohammed N. Nimir (Author), Mohamed D. Dafaalla (Author), Musaab M. Alfaki (Author), Mohamed A. Abdelrahim (Author), Abdelmohaymin A. Abdalla (Author), Musab I. Mohammed (Author), Mona Ellaithi (Author), Muzamil Mahdi Abdel Hamid (Author), Mohamed Ahmed Salih Hassan (Author)
• Format: Book
• Published: BMC, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Breast cancer (BC) is the most common type of cancer in women. Among many risk factors of BC, mutations in BRCA2 gene were found to be the primary cause in 5-10% of cases. The majority of deleterious mutations are frameshift or nonsense mutations. Most of the reported BRCA2 mutat...