Modulation of Multiple Gene Clusters' Expression by the PAS-LuxR Transcriptional Regulator PteF

• Main Authors: Cláudia M. Vicente (Author), Tamara D. Payero (Author), Antonio Rodríguez-García (Author), Eva G. Barreales (Author), Antonio de Pedro (Author), Fernando Santos-Beneit (Author), Jesús F. Aparicio (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PAS-LuxR transcriptional regulators are conserved proteins governing polyene antifungal biosynthesis. PteF is the regulator of filipin biosynthesis from <i>Streptomyces avermitilis</i>. Its mutation drastically abates filipin, but also oligomycin production, a macrolide ATP-synthase inhi...