The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

• Main Authors: Vladimír Sobota (Author), Giulia Gatta (Author), Arne van Hunnik (Author), Iris van Tuijn (Author), Marion Kuiper (Author), James Milnes (Author), Thomas Jespersen (Author), Ulrich Schotten (Author), Sander Verheule (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The acetylcholine-activated inward rectifier potassium current (IKACh) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective IKACh inhibitor XAF-1407, the study investigates the effect of IKACh inhibition in goats with pacing-ind...