The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

• Auteurs principaux: Vladimír Sobota (Auteur), Giulia Gatta (Auteur), Arne van Hunnik (Auteur), Iris van Tuijn (Auteur), Marion Kuiper (Auteur), James Milnes (Auteur), Thomas Jespersen (Auteur), Ulrich Schotten (Auteur), Sander Verheule (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Aims: The acetylcholine-activated inward rectifier potassium current (IKACh) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective IKACh inhibitor XAF-1407, the study investigates the effect of IKACh inhibition in goats with pacing-ind...