Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

• Main Authors: Petr ePavek (Author), Lucie eStejskalova (Author), Lucie eKrausova (Author), Michal eBitman (Author), Radim eVrzal (Author), Zdenek eDvorak (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently sugges...