Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently sugges...

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Main Authors: Petr ePavek (Author), Lucie eStejskalova (Author), Lucie eKrausova (Author), Michal eBitman (Author), Radim eVrzal (Author), Zdenek eDvorak (Author)
Format: Book
Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
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3rd Floor Main Library

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