Rifampicin does not significantly affect the expression of Small heterodimer partner (SHP) in primary human hepatocytes

• Auteurs principaux: Petr ePavek (Auteur), Lucie eStejskalova (Auteur), Lucie eKrausova (Auteur), Michal eBitman (Auteur), Radim eVrzal (Auteur), Zdenek eDvorak (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently sugges...