Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

• Egile Nagusiak: Mouli Chakraborty (Egilea), Chantal Sellier (Egilea), Michel Ney (Egilea), Villa Pascal (Egilea), Nicolas Charlet-Berguerand (Egilea), Ruben Artero (Egilea), Beatriz Llamusi (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2018-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs....