Novel 1,2,3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies

• Main Authors: Bhavna Saroha (Author), Gourav Kumar (Author), Suresh Kumar (Author), Meena Kumari (Author), Manishita Rani (Author), Neera Raghav (Author), Pranab Kumar Sahoo (Author), Sushmita Ghosh (Author), Sutapa Mahata (Author), Vilas D. Nasare (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, we have designed a series of novel 1,2,3-triazole-aurone hybrids, which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ generated azide, and evaluated as potential cathepsin B inhibitors. The structures of the synthesized compounds were con...