Novel 1,2,3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies

• Những tác giả chính: Bhavna Saroha (Tác giả), Gourav Kumar (Tác giả), Suresh Kumar (Tác giả), Meena Kumari (Tác giả), Manishita Rani (Tác giả), Neera Raghav (Tác giả), Pranab Kumar Sahoo (Tác giả), Sushmita Ghosh (Tác giả), Sutapa Mahata (Tác giả), Vilas D. Nasare (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2022-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

In the present study, we have designed a series of novel 1,2,3-triazole-aurone hybrids, which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ generated azide, and evaluated as potential cathepsin B inhibitors. The structures of the synthesized compounds were con...