ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3

ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3

Abstract Background Rare variants in epigenes (a.k.a. chromatin modifiers), a class of genes that control epigenetic regulation, are commonly identified in both pediatric neurodevelopmental syndromes and as somatic variants in cancer. However, little is known about the extent of the shared disruptio...

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Main Authors: Isabella Lin (Author), Zain Awamleh (Author), Mili Sinvhal (Author), Andrew Wan (Author), Leroy Bondhus (Author), Angela Wei (Author), Bianca E. Russell (Author), Rosanna Weksberg (Author), Valerie A. Arboleda (Author)
Format: Book
Published: BMC, 2024-11-01T00:00:00Z.
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3rd Floor Main Library

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