ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3

• 主要な著者: Isabella Lin (著者), Zain Awamleh (著者), Mili Sinvhal (著者), Andrew Wan (著者), Leroy Bondhus (著者), Angela Wei (著者), Bianca E. Russell (著者), Rosanna Weksberg (著者), Valerie A. Arboleda (著者)
• フォーマット: 図書
• 出版事項: BMC, 2024-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Rare variants in epigenes (a.k.a. chromatin modifiers), a class of genes that control epigenetic regulation, are commonly identified in both pediatric neurodevelopmental syndromes and as somatic variants in cancer. However, little is known about the extent of the shared disruptio...