High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain

• मुख्य लेखकों: Tanima Chatterjee (लेखक), Itika Arora (लेखक), Lilly Underwood (लेखक), Anastasiia Gryshyna (लेखक), Terry L. Lewis (लेखक), Juan Xavier Masjoan Juncos (लेखक), Burel R. Goodin (लेखक), Sonya Heath (लेखक), Saurabh Aggarwal (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

An overwhelming number of people with HIV (PWH) experience chronic widespread pain (CWP) throughout their lifetimes. Previously, we demonstrated that PWH with CWP have increased hemolysis and attenuated heme oxygenase 1 (HO-1) levels. HO-1 degrades reactive, cell-free heme into antioxidants like bil...