High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain

• Главные авторы: Tanima Chatterjee (Автор), Itika Arora (Автор), Lilly Underwood (Автор), Anastasiia Gryshyna (Автор), Terry L. Lewis (Автор), Juan Xavier Masjoan Juncos (Автор), Burel R. Goodin (Автор), Sonya Heath (Автор), Saurabh Aggarwal (Автор)
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• Опубликовано: MDPI AG, 2023-06-01T00:00:00Z.
• Предметы: article
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An overwhelming number of people with HIV (PWH) experience chronic widespread pain (CWP) throughout their lifetimes. Previously, we demonstrated that PWH with CWP have increased hemolysis and attenuated heme oxygenase 1 (HO-1) levels. HO-1 degrades reactive, cell-free heme into antioxidants like bil...