PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

• প্রধান লেখক: Maria Franz (লেখক), Ravi Kumar Jairam (লেখক), Lars Kuepfer (লেখক), Nina Hanke (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

IntroductionAnimal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose estimates it is essential to assess the comparability of animal studies with the human...