PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

IntroductionAnimal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose estimates it is essential to assess the comparability of animal studies with the human...

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Main Authors: Maria Franz (Author), Ravi Kumar Jairam (Author), Lars Kuepfer (Author), Nina Hanke (Author)
Format: Book
Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
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