PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

• Những tác giả chính: Maria Franz (Tác giả), Ravi Kumar Jairam (Tác giả), Lars Kuepfer (Tác giả), Nina Hanke (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

IntroductionAnimal models play a vital role in pharmaceutical research and development by supporting the planning and design of later clinical studies. To improve confidence and reliability of first in human dose estimates it is essential to assess the comparability of animal studies with the human...